Combined xeno/auto-grafting of a benign osteolytic lesion in a dog, using a novel bovine cancellous bone biomaterial

Authors: Firth EC, Owen MC, Worth AJ, Mucalo MR, Thompson KG
Publication: New Zealand Veterinary Journal, Volume 55, Issue 3, pp 143-148, Jun 2007
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Animal remedies/veterinary medicines, Skeletal/bone/cartilage, Diagnostic procedures, Legal/regulation, Imaging, Surgery
Article class: Clinical Communication

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Abstract: CASE HISTORY: A 4-year-old female Labrador Retriever was diagnosed with an osteolytic lesion of the right distal radius.
CLINICAL FINDINGS: Radiographs indicated a well-circumscribed radiolucent area 18 x 15 x 8 mm, centred on the distal radial physeal scar.
DIAGNOSIS: Histopathology, performed via Jamshidi needle biopsy and following surgical curettage, was inconclusive but suggested either an aneurysmal bone cyst or fibrous dysplasia.
CLINICAL RELEVANCE: A novel processed cancellous bovine bone xenograft was used in conjunction with autogenous cancellous bone (at a ratio of approximately 4:1) to fill the curetted defect. There were no observed complications associated with the use of this new biomaterial. Osteointegration of the bone graft was followed using conventional radiographs and peripheral quantitative computed tomography (pQCT) for 10 months post-operatively. Radiographically, the osteolytic lesion modelled to resemble metaphyseal trabeculation. The cross-sectional area and the average bone density of the grafted lesion determined using pQCT data increased over time, suggesting healthy osteoconduction and native bone production.
KEY WORDS: Bovine cancellous bone, xenograft

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