Endoscopic evaluation of the gastroduodenal mucosa following non-steroidal anti-inflammatory drug administration in the dog

Authors: Lawoko CRO, Forsyth SF, Guilford WG
Publication: New Zealand Veterinary Journal, Volume 44, Issue 5, pp 179-181, Oct 1996
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Abdomen, Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Inflammation, Treatment/therapy, Antinflamatory, Diagnostic procedures, Imaging
Article class: Scientific Article

---

Abstract: The gastroduodenal mucosa of 30 healthy dogs was examined by endoscope after 7 days of oral non-steroidal anti-inflammatory drug administration. The dogs were divided into five groups. One group received ketoprofen (1 mg/kg every 24 h), one group copper-indomethacin (0.2 mg/kg every 12 h), one group 1 mg of prednisolone and 200 mg of cinchophen (1 tablet per 20 kg every 12 h), one group aspirin (15 mg/kg every 12 h) and one group gelatin (1 capsule every 12 h). Occult blood was not detected in the faeces either prior to or after non-steroidal anti-inflammatory drug administration. Packed cell volume, total plasma protein and buccal mucosal bleeding times did not significantly change after non-steroidal antiinflammatory drug administration. Gastroduodenal lesions were observed in 22 dogs. There was no significant difference in lesions between the ketoprofen, copper-indomethacin and prednisolone-cinchophen groups, but the gelatin group had significantly (p ≤0.05) fewer severe lesions and the aspirin group had significantly (p ≤0.05) more severe gastric lesions. The gastroduodenal lesions were mild and none of the dogs showed any clinically adverse effect.

---