A new diagnostic opportunity: DNA probes

Authors: Murray A, Moriarty KM
Publication: New Zealand Veterinary Journal, Volume 37, Issue 2, pp 45-46, Jun 1989
Publisher: Taylor and Francis

Animal type: General
Subject Terms: DNA/RNA, Diagnostic procedures
Article class: General Article

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Abstract: In the 36 years since Watson and Crick proposed the double helix structure for DNA, molecular biology has evolved from a highly specialized, academic pursuit into the most dynamic and influential life science of the 20th century. An enormous literature now deals with DNA and its manipulation with much attention focussing on DNA probe technology. DNA probes can provide rapid, sensitive and specific identification of micro-organisms. They have already had a major impact on diagnostic microbiology in human medicine and it is likely that probes will eventually be developed for all important infectious agents. It is therefore important that veterinarians should become familiar with some of the terminology associated with DNA probes and be aware of their diagnostic potential. This article will outline some of the basic techniques used in probe construction and introduce some terms commonly used in this emerging technology.

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