Naproxen poisoning in a dog

Authors: Carbery JT
Publication: New Zealand Veterinary Journal, Volume 34, Issue 5, pp 76, May 1986
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Adverse drug reaction, Animal remedies/veterinary medicines, Inflammation, Treatment/therapy, Antinflamatory, Poisoning - chemical, Toxicology
Article class: Correspondence

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Abstract: Naproxen, marketed under the trade-name “Naprosyn”, is a propionic acid derivative related to the arylacetic acid class of drugs and unrelated to the salicylates and the corticosteroid hormones. It is used in humans as an antiinflammatory agent, particularly in the treatment of rheumatoid arthritis, osteoarthritis and primary dysmennorrhoea. In the human, adverse reactions involve the gastro-intestinal tract, the liver, skin, CNS, and the cardiovascular system. Clinical features of overdosage include nausea, indigestion and epigastric pain. The subject of this report, a mature mixed-breed dog of approximately 11 kg, was presented with a history of vomiting, having consumed an indeterminate number of its owner`s naproxen tablets. The animal evinced signs of pain on palpation of the epigastric region, and appeared somewhat anxious. No signs of involvement of other systems were noticed. Following consultation with the owner`s physician a presumptive diagnosis of naproxen overdose was made…

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