Treatment of 1080 poisoning in dogs with glycerol monoacetate

Authors: Julian AF, Livingstone PG, Hoogenboom JJL, Rammell CG
Publication: New Zealand Veterinary Journal, Volume 33, Issue 9, pp 149-150, Sep 1985
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Toxicology, Pest/pesticides, Poisoning - chemical, Poisoning, Parasites - external, Treatment/therapy
Article class: Correspondence

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Abstract: Poisoning of dogs by Compound 1080 (sodium monofluoroacetate) during vertebrate pest control operations is relatively common and a cause of concern to farmers. Precautions against such poisoning include secure chaining, fitting of protective muzzles or biting chains, and adequate feeding to reduce the tendency for dogs to eat poisoned carcasses. If the dog is seen to eat a carcass then emetic capsules, containing 1 g of zinc sulphate and obtainable from local Pest Boards, may have some protective value if given straightaway. The treatment recommended for 1080 poisoning in humans includes intravenous infusion of acetamide or glycerol monoacetate (GMA), or intramuscular injection of GMA. The recommended treatment for any human 1080 poisoning cases in N.Z. is 500 ml of acetamide (10% in 5% glucose) by rapid intravenous infusion for the first 30 minutes and then 200 ml four-hourly. An earlier recommendation was for the intramuscular injection of 0.1-0.5 ml 60% GMA/ kg. The World Health Organisation suggested intramuscular injection of 0.5 mg GMA/kg every 30 minutes for 12 hours…

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