Anthelmintics - a review: Part II

Authors: Barragry T
Publication: New Zealand Veterinary Journal, Volume 32, Issue 11, pp 191-199, Nov 1984
Publisher: Taylor and Francis

Animal type: Livestock
Subject Terms: Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Nervous system/neurology, Toxicology, Pharmacology, Poisoning - chemical, Treatment/therapy
Article class: Review Article

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Abstract: A large number of related compounds, all based on the prototype parent compound thiabendazole are now available on the market, each one claiming distinct advantages and applications for anti-parasitic use. The ever increasing number of benzimidazoles appearing regularly is a good example of so called molecular manipulation of molecular roulette whereby individual pharmaceutical companies endeavour to compete with a rival company`s successful product without breaching the patent rights of a particular compound. Currently a number of products are available including Thiabendazole (TBZ), Cambendazole (CBZ), Parbendazole (PBZ), Mebendazole (MBZ), Fenbendazole (FBZ), Oxfendazole (OFZ), Oxibendazole (OBZ). Albendazole (ABZ) and probenzimidazoles Thiophante and Febantel which are metabolized in the animal body to the true benzimidazole carbamate nucleus. All of these substances are characterised by a very low mammalian toxicity; it is virtually impossible to find an LD50 for some of these compounds. Some of the benzimidazoles are teratogenic and depending on the dose rate, are contra-indicated in early pregnancy. Early benzimidazoles such as thiabendazole were quite soluble and rather quickly eliminated from the body…

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