Failure to induce contact hypersensitivity in the opossum, Trichosurus vulpecula

Authors: Thomas MJ, Moriarty KM
Publication: New Zealand Veterinary Journal, Volume 30, Issue 10, pp 160, Oct 1982
Publisher: Taylor and Francis

Animal type: Possum, Wildlife
Subject Terms: Allergy, Integument/skin/wool/hair/fur/feather
Article class: Correspondence
Abstract: Contact hypersensitivity (CHS; syn: contact allergy, contact dermatitis, contact eczema) is induced when chemicals (haptens) capable of binding covalently to autologous proteins are applied to the skin. The hapten-protein complexes formed in this way are immunogenic and elicit the immune response underlying CHS. CHS is a form of delayed hypersensitivity. Exposure of a primed animal to the sensitising hapten results in erythema and induration at the site of skin contact, the response being maximal after 24 hours. CHS is seen in chickens, mice, rats, rabbits, guinea pigs, hamsters, dogs, pigs, monkeys, man and other species, the preferred animal for experimental investigations being the guinea pig…
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