Protection of cattle against natural challenge with Leptospira interrogans serovar hardjo using a hardjo-pomona vaccine

Authors: Hellstrom JS, Marshall RB, Broughton ES
Publication: New Zealand Veterinary Journal, Volume 27, Issue 6, pp 114-116, Jun 1979
Publisher: Taylor and Francis

Animal type: Cattle, Livestock, Production animal, Ruminant
Subject Terms: Animal remedies/veterinary medicines, Bacterial, Immune system/immunology, Zoonosis, Disease/defect, Infectious disease, Vaccination, Public health
Article class: Scientific Article

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Abstract: The hardjo component of a bivalent hardjo/pomona vaccine prepared from cultures grown in a protein-free medium was tested in calves which experienced a natural challenge about 7 months after vaccination. A significant degree of protection was obtained using either seroconversion or positive urine cultures as indicators of infection. Seroconversion occurred in 10/10 nonvaccinates and 2/9 vaccinates (p<0.01), Leptospires of serovar hardjo were isolated from the urine of 6/10 non-vaccinated calves and 0/9 vaccinated animals (p<0.05).

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