Deaths in sheep after overdosage with thiabendazole

Authors: Clark RG, Lewis KHC
Publication: New Zealand Veterinary Journal, Volume 25, Issue 7, pp 187-190, Jul 1977
Publisher: Taylor and Francis

Animal type: Livestock, Production animal, Ruminant, Sheep
Subject Terms: Adverse drug reaction, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Mortality/morbidity, Poisoning - chemical, Treatment/therapy, Toxicology
Article class: Scientific Article

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Abstract: 160 Romney ewes drenched with thiabendazole at 11 to 17 times the recommended dose resulted in 35 deaths. No deaths occorred in an equal number of undrenched ewes or in an equal number of ewes drenched with the recommended dose. Clinical signs, necropsy, histopathology and biochemical findings are reported. Deaths were associated with hypokalaemia, hypoproteinaemia and uremia, and were considered to have been the result of overdosage with thiabendazole.

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