An anaemic state in a horse associated with a cold-acting antibody

Authors: Sutton RH, Brown MF, Moriarty KM
Publication: New Zealand Veterinary Journal, Volume 24, Issue 5, pp 85-92, May 1976
Publisher: Taylor and Francis

Animal type: Horse, Livestock
Subject Terms: Circulatory system/haematology, Disease/defect, Clinical pathology, Diagnostic procedures, Immune system/immunology, Pathology
Article class: Scientific Article

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Abstract: Auto-immune haemolytic anaemias (AHA) of man (Dacie, 1963) and domesticated animals (Schalm, 1965; Farrelly et al, 1966; Lapras and Oudar, 1971) are classified either as idiopathic or secondary to an underlying disease process (Pirofsky, 1969). In both categories antibodies active against the individual`s own erythrocytes are formed. These autoantibodies are of two types being either warm or cold-acting. Warm-acting antiboldies are moist effective at 37°C, belong to the IgG class of immunoglobulins, and are incomplete in that, generally, they do not cause autohaemagglutination. Cold-acting, or cryopathic, antibodies show maximnm activity at 4°C are of the IgM immunoglobulin class and are capable of effecting autohaemagglutination. The two types of antibodies also differ in their prevalence…

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