Critical test evaluation of micronized mebendazole against Anoplocephala perfoliata in the horse

Authors: Bain SA, Kelly JD
Publication: New Zealand Veterinary Journal, Volume 23, Issue 10, pp 229-232, Oct 1975
Publisher: Taylor and Francis

Animal type: Horse, Livestock
Subject Terms: Abdomen, Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Treatment/therapy, Nematode
Article class: Scientific Article

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Abstract: Mebendazole (methyl 5(6)benzoyl 1-2 benzimidazole carbamate) has recently been shown to have high anthelmintic efficacy against a wide range of benzimidazole-susceptible nematodes (Callear and Neave, 1971; Walker and Knight, 1972; Bennett, 1973; Bradley and Radhakrishnan, 1973; Neave and Callear, 1973; Reinecke and LeRoux, 1973). However, its activity against equine cestodes is generally reported to be unsatisfactory - e.g. Bradley and Radhakrishnan ( 1973) using mebendazole at a dose rate of 9 mg/kg (administered either per os or by stomach tube), did not observe significant anthelmintic efficacy against Anoplocephala spp. in horses. Similar results were reported by Drudge et al (1974) for mebendazole (8.8 mg/kg administered by stomach tube) against both Anoplocephala magna and A. perfoliata. Mebendazole is only sparingly soluble in water (and most organic and inorganic solvents) and is currently prepared for use as an aqueous suspension or as granulated dry feed…

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