Induction of luteolysis and oestrus in mares with a synthetic prostaglandin analogue (ICI 81008)

Authors: Berwyn-Jones MD, Irvine CHG
Publication: New Zealand Veterinary Journal, Volume 22, Issue 7, pp 107-110, Jul 1974
Publisher: Taylor and Francis

Animal type: Horse, Livestock
Subject Terms: Diagnostic procedures, Endocrine/autocrine/paracrine, Oestrus/oestrous, Reproduction - female, Reproduction, Reproduction - hormones, Research/development
Article class: Scientific Article

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Abstract: Cyclical regression of the corpus luteum is induced by an uterine luteolysin which has been shown in several species to be prostaglandin F_2α (PGF_2α) although it is not yet known how it achieves its effect. Much of the early work on the induction of luteolysis in the mare by Allen and Rowson (1973) and Allen and Rossdale (1973) entailed the use of either natural PGF_2α or earlier analogues (notably ICI 79939) but unfortunately these produced adverse side-effects when given by intramuscular injection. These disadvantages have been overcome by the development of a safer synthetic PG analogue ICI 81008 (Allen et al 1974). A trial using this analogue on 100 mares at New Zealand studs is reported here.

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