Treatment of bovine mastitis with Rifamycin SV

Authors: Coxhead NL, Wanstall RN, Buchanan RS
Publication: New Zealand Veterinary Journal, Volume 21, Issue 6, pp 116-122, Jun 1973
Publisher: Taylor and Francis

Animal type: Cattle, Livestock, Production animal, Ruminant
Subject Terms: Animal remedies/veterinary medicines, Antibiotics, Treatment/therapy, Bacterial, Mammary gland/udder, Mastitis, Infectious disease, Disease/defect
Article class: Scientific Article

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Abstract: Rifamastene is a water-miscible formulation of the new antibiotic rifamycin SV designed for use as an udder infusion for the treatment of bovine mastitis. Literature reporting the activity and properties of rifamycin SV was recently reviewed by Radaelli et al (1971) from which the following descriptions of the properties, toxicity and udder tolerance are summarized. The rifamycins are a family of antibiotics isolated from the fermentation broth of Streptomyces mediterranei. Rifamycin SV was obtained from one of these substances. It is chemically different from other known antibiotics and is particularly active against Gram-positive micro-organisms and mycobacteria. It was introduced into human clinical practice in 1962 for the treatment of Staphylococcus and other Gram-positive infections. Rifamycin acts as a bactericide attacking micro-organisms in their multiplication phase…

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