Studies on inflammation in the sheep, using turpentine-induced pleurisy as a test system. 2. Suppression of the increased vascular permeability by specific antagonists of chemical mediators, anti-inflammatory agents and other substances

Authors: Vegad JL, Lancaster MC
Publication: New Zealand Veterinary Journal, Volume 21, Issue 5, pp 90-97, May 1973
Publisher: Taylor and Francis

Animal type: Livestock, Production animal, Ruminant, Sheep
Subject Terms: Biochemistry/chemistry, Immune system/immunology, Inflammation, Research/development, Respiratory system
Article class: Scientific Article

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Abstract: In a previous communication it was reported that a biphasic increase in vascular permeability occurs following intradermal injection of turpentine in the sheep; an early phase seems to be mediated by histamine (Lancaster and Vegad, 1967). Later experiments depleting sheep of their stores of histamine by compound 48/80, a histamine liberator, have confirmed the biphasic nature of the increase in vascular permeability in turpentine-induced pleurisy in the sheep and mediation of the early phase by histamine (Vegad, 1971a). Histamine is also released in the sheep in the early phase of inflammation following thermal injury (Vegad, 1971b), and in the cutaneous antigen-antibody reactions (Vegad and Lancaster, 1972a). Despite this, however, mediation of the increased vascular permeability in the delayed phase of the inflammatory reaction, which appears to be the major part of the response, remains uncertain: this is similar to the situation both in the rat (Spector and Willoughbv, 1965) and in the guinea-pig (Wilhelm, 1965, 1968). Recent investigations into the mediation of the delayed phase in the rat and the guinea-pig, however, suggest that mediation of this phase may depend on the, formation of kinins by a “globulin-kinin forming system”, activated following injury…

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