Studies on inflammation in the sheep, using turpentine-induced pleurisy as a test system 1. Studies on the pleural exudates

Authors: Vegad JL, Lancaster MC
Publication: New Zealand Veterinary Journal, Volume 20, Issue 12, pp 232-237, Dec 1972
Publisher: Taylor and Francis

Animal type: Livestock, Production animal, Ruminant, Sheep
Subject Terms: Notifiable organisms/exotic disease, Pneumonia/pleurisy, Disease/defect, Respiratory system, Infectious disease, Research/development
Article class: Scientific Article

---

Abstract: A biphasic increase in vascular permeability occurs following turpentine and thermal injury in the sheep; an early phase seems to be mediated by histamine (Lancaster and Vegad, 1967; Vegad, 1971). In contrast, mediation of the delayed phase, which appears to be the major part of the response, remains uncertain. This is similar to the situation in the rat (Spector and Willoughby, 1965) and the guinea-pig (Wilhelm, 1965).  However, recent investigations in the rat and the guinea-pig into the mediation of the delayed phase suggest that mediation of the delaved phase may depend on the formation of kinins by a “globulin-kinin forming system” activated following injury…

---