Some aspects of the pharmacology of pyrantel in the dog

Authors: Forbes LS
Publication: New Zealand Veterinary Journal, Volume 20, Issue 6, pp 83-85, Jun 1972
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Nervous system/neurology, Pharmacology, Respiratory system, Treatment/therapy
Article class: Scientific Article

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Abstract: Acetylcholine and cholinesterase occur in many different species of unicellular and multicellular animals and their presence is often related to nerve and muscle activity and to movement. The substances occur in parasitic helminths and several modern anthelmintics appear to act by disrupting cholinergic mechanisms. One such group, the organophosphorus compounds inactivate cholinesterase allowing preservation of endogenous acetylcholine and consequent interference with normal motor activity. A second group owes its basic mode of action to chemical and biological features shared with acetylcholine and acts, essentially, by mimicking the effects of excessive amounts of the natural neurotransmitter…

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