Suspected oesophageal adenocarcinoma associated with Barrett's oesophagus in a brachycephalic dog with chronic gastroesophageal reflux

Authors: Nash TR, Hosgood GL, Coiacetto F
Publication: Australian Veterinary Practitioner, Volume 54, Issue 4, pp 172-177, Dec 2024
Publisher: Australian Veterinary Association

Animal type: Dog
Article class: Clinical Article

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Abstract:

Case report: A 9-year-old, spayed female Boston terrier was diagnosed with a distal oesophageal mass via upper gastroesophageal endoscopy. Pinch biopsies were most consistent with oesophageal adenocarcinoma. The mass was associated with oesophageal intestinal metaplasia that had histologic features of Barrett’s oesophagus, as described in people. Pinch biopsies of the stomach and duodenum were consistent with mild to moderate lymphoplasmacytic and eosinophilic to occasionally neutrophilic gastroenteritis. The dog had a history of chronic, intermittent regurgitation and was diagnosed with oesophageal hiatal laxity, evidenced by herniation of the cardia through the diaphragm observed on abdominal ultrasonography. It is suspected that chronic regurgitation induced reflux oesophagitis and oesophageal intestinal metaplasia, which may have subsequently progressed to oesophageal adenocarcinoma.

Conclusion: This report suggests oesophageal adenocarcinoma in dogs may develop secondary to reflux oesophagitis and Barrett’s oesophagus, as described in people.

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