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Plasma free metanephrines before and after adrenalectomy in a cat with phaeochromocytoma
Authors: Chau L, Mackie JT, Korman RPublication: Australian Veterinary Practitioner, Volume 54, Issue 1, pp 47-57, Mar 2024
Publisher: Australian Veterinary Association
Animal type: Cat
Article class: Clinical Article
Abstract:
Pheochromocytoma is a rare adrenal tumour in cats and preoperative diagnosis is often challenging. A 10-year-old neutered male Russian Blue cat presented with tetraparesis, persistent marked tachycardia, cortical blindness, severe hypertension and bilateral partial retinal detachments. Ultrasound identified a right adrenal mass without caudal vena caval invasion. Markedly increased plasma free normetanephrine (pfNMN) concentration supported a diagnosis of phaeochromocytoma. Plasma aldosterone concentration was normal. The cat’s neurological signs resolved with medical management including amlodipine, atenolol and spironolactone. It subsequently developed diabetes mellitus and severe anaemia. Following stabilization with phenoxybenzamine, right adrenalectomy was performed via ventral midline approach. Histopathology confirmed an adrenal medullary neoplasm, that was immunoreactive to antibodies against synaptophysin, consistent with a phaeochromocytoma. Both plasma free normetanephrine (pfNMN) and plasma free metanephrine (pfMN) concentrations markedly reduced following adrenalectomy.
Keywords: adrenal tumour, phaeochromocytoma, metanephrine, normetanephrine, adrenectomy
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