Serum Symmetric dimethylarginine (SDMA) concentrations in a population of dogs with multicentric large B cell lymphoma

Authors: Tena A, Fry DR
Publication: Australian Veterinary Practitioner, Volume 54, Issue 1, pp 31-38, Mar 2024
Publisher: Australian Veterinary Association

Animal type: Dog
Article class: Clinical Article

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Abstract:

Increased symmetric dimethylarginine (SDMA) has been reported in some dogs with lymphoma at the time of diagnosis. We aimed to assess whether Australian dogs with multicentric-large-B-cell-lymphoma (MLCBL) without known renal disease have an increased SDMA at the time of diagnosis compared with a control group.

Medical records of an Australian private referral hospital were reviewed to identify dogs with multicentric-large-B-cell-lymphoma and controls with serum SDMA concentrations and renal parameters measured at the time of diagnosis between 2018-2023. Serum creatinine, SDMA, urine specific gravity and body condition score between the two groups were compared using the Mann Whitney U test. P < .05 was considered statistically significant.

A total of 17 dogs diagnosed with MLBCL and 15 controls were included. Median SDMA was 12 ug/dL (IQR, 10; 19) in dogs with MLCBL and 8 ug/dL (IQR, 6; 10) in the control group.

This highlights the need for careful interpretation of SDMA concentration in dogs with newly diagnosed MCBCL, as increases may be present and not associated with renal disease.

Keywords: lymphoma, canine, dog, multicentric, diffuse, SDMA, creatinine, renal.

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