Resistance to a triple-combination anthelmintic in Trichostrongylus spp. on a commercial sheep farm in New ZealandAuthors: Mulvaney CJ, Hodgson BAS
Publication: New Zealand Veterinary Journal, Volume 65, Issue 5, pp 277-281, Sep 2017
Publisher: Taylor and Francis
AIM: To evaluate resistance to anthelmintics containing abamectin, levamisole, and oxfendazole (AB-LEV-OX), derquantal and abamectin (DEQ-AB), moxidectin, and monepantel in naturally acquired gastrointestinal nematodes present on a sheep farm.
METHODS: Faecal nematode egg count reduction tests (FECRT) were carried out on lambs that were approximately 7 months-old and infected with naturally acquired nematodes. Lambs were randomly allocated to one of five groups (n=15 per group): treatment with 2â€…mg/kg derquantel and 0.2â€…mg/kg abamectin; 0.2â€…mg/kg abamectin, 8â€…mg/kg levamisole HCl and 4.5â€…mg/kg oxfendazole; 2.5â€…mg/kg monepantel; 0.2â€…mg/kg moxidectin, or no treatment. Post-treatment samples were collected 12 days later. Abomasa and small intestines were collected from two slaughtered lambs from each of the DEQ-AB, AB-LEV-OX, moxidectin and control groups 15 days after treatment, for nematode counting.
RESULTS: The FECRT demonstrated that efficacy was 90.3 (95% CI=84.2â€“94.1)% for AB-LEV-OX, 54.5 (95% CI=28.4â€“71.1)% for moxidectin, 99.2 (95% CI=97.4â€“99.8)% for DEQ-AB and 100% for monepantel, across all genera. For
CONCLUSIONS: Anthelmintic resistance to both AB-LEV-OX and moxidectin was present in the
CLINICAL RELEVANCE: This finding of resistance to an AB-LEV-OX triple-combination anthelmintic in the
KEY WORDS: Anthelmintic, resistance, Trichostrongylus, triple combination, moxidectin, gastrointestinal, nematode, sheep